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6.1.2 Inhibitors targeting key SSP enzymes Developing inhibitors against key enzymes in the de novo serine synthesis pathway has become an important direction for pan-cancer therapy

-Syn oligomers can also inhibit the import of proteins, including some subunits of complex I, into the mitochondria by binding to the translocase of the outer membrane (TOM20) and inhibiting its interaction with the co-receptor TOM22 (Di Maio et al., 2016)

The structures and function become important when we talk about supplementation

BRCA1 and BRCA2 mutations and treatment strategies for breast cancer

This inhibition reduces the antioxidant capacity of cells, leading to an accumulation of ROS, causing further damage to cellular components and expediting cellular aging (Tan et al., 2020)

All of which means that standard oral glutathione supplements are often poorly absorbed