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Symptoms Severe vitamin E deficiency results mainly in neurologic symptoms, including impaired balance and coordination (spinocerebellar ataxia), injury to the sensory nerves (peripheral neuropathy), muscle weakness (myopathy), and damage to the retina of the eye (retinopathy)

These models are comprehensive systems that incorporate detailed patient histories, treatment records, and whole exome sequencing (WES) data

Endocytosis Vesicular formation at the cell membrane that involves engulfing the surrounding materials

It is also remarkable that some autophagy-inducing compounds, such as berberin, have the ability to increase Atg7 levels along with Atg5, making it interesting to test this compound in the effort to antagonize OHC pathology [65] (Figure 17 and Figure 18)

Toxicol Appl Pharmacol 146(1):127133

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