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With the sub-toxic dose of 0.1 mM, the low gradient of 40 is temporary, with cells rapidly starting to recover the Tpx1-driven gradient of 300, while with the toxic dose of 0.5 mM the gradient collapse is much more sustained and does not recover even after 50 min

Be sure to consult your doctor before making any significant change to diet or supplementation

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It will be interesting to test whether these mutants, or other mutants defective for dauer pheromone sensing and/or signaling exhibit an increase or decrease in longevity

What Should Be Considered Before Treatment

If you fall into any of these categories, it's worth discussing B12 testing with your healthcare provider