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Cell proliferation induced by GPE was further delineated by an increased level of phosphorylated Akt, indicating potential upregulation of the ERK ( Figure 6 ) and PI3K/Akt signaling pathways ( Figure 7 ) pathways, which are among the signaling pathways involved in the regulation of cell proliferation

Upon ERK5 overexpression, AX15836 significantly increased MEF2-driven luciferase activity, confirming ERK5 transcriptional activation

Ethnicity is a significant determinant of risk

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and vitamin K.13 Thus, gut microbiota also influence nutrient availability and neuronal integrity

doi: 10.1038/s41388-022-02559-5