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Plots showing a linear correlation (r2 = 0.994) between the GSH signal area at 2.95 ppm and the concentration of GSH

These include widespread inflammation which impacts sensory nerve pain, metabolic changes, leaky blood and lymphatic vessels, tissue hypoxia, presence of VEGF (which stimulates new, but abnormal blood vessel growth), and abnormal quantity and size of fat cells

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These have included once again size [315, 316] and also crystalline nature [317], adsorptive ability of alveolar and serum components as well benzo(a) pyrene [318,319,320,321], and dissolution and biodegradation of mineral fibres [322, 323]

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During the degradation stage, the autophagosome fuses with a lysosome, and lysosomal hydrolases degrade its cargo