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Thromb Haemost 2010;104:42431

Methemoglobin Reduction Most methemoglobin in the erythrocyte is reduced through the action of an enzyme cytochrome b5 methemoglobin reductase, which acts in the presence of two electrons carriers, cytochrome b5, and NADH

doi: 10.1038/nrn2417 129

This regulatory pathway highlights ANO6 as a potential therapeutic target for treating GISTs by leveraging its role in ferroptosis and ChaC1 regulation (Wang et al., 2024)