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SYK deficiency significantly reduced levels of key glycolytic intermediates (glucose 6-phosphate, fructose-1,6-bisphosphate, phosphoenolpyruvate, pyruvate, lactate), tricarboxylic acid (TCA) cycle components (acetyl-CoA, citrate, succinate), and oxidative phosphorylation (OXPHOS) metabolites (ATP, NAD + )