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Therefore, more studies are needed to clarify these conflicting findings and strengthen interpretations of APOE4 s effects on cognitive changes in PD and DLB

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Although beyond the primary scope of this review, it is worth mentioning that emerging evidence highlights the gut microbiome as a potential mediator of circadian disruption-associated breast carcinogenesis, with studies indicating that NSW can alter microbial composition and diurnal rhythmicity, thereby modulating systemic inflammation, estrogen metabolism, and immune function, all of which are relevant to BC risk 260