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Nature Reviews Neuroscience , 12 , 685700

Contribution of nad(P)H:Quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

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Notably, p53-dependent activation of GLS-2 expression correlates with ROS, while elevated ROS levels lead to p53 stabilization and activation [89]

Comparative radar chart of the clinical efficacy of selected supplements in PCOS management

The predominant RNS is nitric oxide radical (NO ) [36], formed in biological tissues from the oxidation of L-arginine to citrulline by nitric oxide synthase [37, 38], and precursor of other two RNS, the peroxynitrite (ONOO ), and the nitrogen dioxide radical ( NO 2 ) (Fig