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J.JungY.-J

[49] found a moderate increase in desipramine disposition (5865% and 24% for AUC and C max , respectively) in nine healthy subjects concomitantly treated with cobicistat

Raza H, Ahmed I, John A, Sharma AK

& Poston, K

However, if the concentration of a metabolite that is distal to the metabolic reaction is expressed as a ratio to a metabolite that is proximal to the metabolic reaction, that ratio may reveal a change in that pathway that could otherwise go undetected