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This network operates as a multidimensional system in which microbiota remodeling initiates the intervention, barrier function provides support, immune regulation drives the response, and antioxidant defenses sustain it (Xu et al., 2025)

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The mechanism involves isotretinoin's activation of retinoid X receptors (RXR), which reduces hepatic lipase activity and increases very-low-density lipoprotein (VLDL) secretion