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Dacomitinib effectively penetrates GBM tumors, with 14.3% of patients experiencing clinical benefit and 8.9% achieving PFS for at least one year

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In these settings and others, he has used case-control, cohort, clinical-trial and meta-analytic methods to evaluate the risks and benefits of a variety of medications, including hormone therapy, non-steroidal anti-inflammatory agents, and drugs used to treat hypertension, diabetes, dyslipidemia, asthma, heart failure, atrial fibrillation, osteoporosis, chronic pain, and other conditions as well as drug-gene interactions that may influence the risk-benefit profile of selected medications