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Ruizeveld de Winter JA, et al

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By bypassing the rate-limiting step of glycolysis catalyzed by phosphofructokinase, fructose not only provides more substrate to DNL than glucose, but also occurs independent of insulin and the energy status of the cell [98], leading to an energy mismatch and subsequently promoting oxidative stress and insulin resistance [99,100]

Dietary choline intake: current state of knowledge across life cycle

(2011), which revealed that choline, TMAO and betaine were predictors of CVD risk

Additionally, UA has demonstrated neuroprotective effects against oxidative stress caused by hydrogen peroxide (H2O2), thereby safeguarding neuronal survival in the face of elevated levels of reactive oxygen species (ROS) (Figure 5)