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Name: deubiquitinase glutathione Frontiers Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity
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References Ramos, S

Drug Des Methodol Concepts, Mode-of-Action

Ferroptosis and related genes may serve as promising targets for the treatment of SSc [238]

For example, the FAO inhibitor etomoxir reversed cisplatin resistance in cisplatin-resistant cells from OC and GC [57, 64], perhexiline reversed AUY922 resistance in PCa cells [51], and thiolidazine reversed enzalutamide resistance in PCa cells [155]

Mitochondrial damage causes ATP depletion and ROS burst, exacerbating inflammation and disrupting the intestinal barrier

Previous studies have confirmed the above view that in the post-arthroplasty tissues of patients with RA, RNAKL is mainly expressed at the endothelial-bone interface and subchondral bone erosion sites, the site of contact between the pannus and cartilage (236)