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Recent studies (2023-2025) have demonstrated that IL-17A directly upregulates pro-ferroptotic mediators such as ACSL4 while suppressing protective factors like myocyte enhancer factor 2C (MEF2C) in airway epithelium, thereby creating a feed-forward loop of lipid peroxidation (129131)

Only moderate or nonglomerular hypertrophy was noted in acromegalic patients undergoing kidney biopsy

Another is more substrates from the first third of the TCA cycle, including glutamate, a precursor to GABA, and citrate, a precursor to cytosolic acetyl-CoA and acetylcholine synthesis

10.1002/glia.21176 322 SepehrmaneshZ.HeidaryM.AkashehN.AkbariH.HeidaryM

doi: 10.1136/jmg.2003.012047 119

On examination, signs of chronic liver disease such as spider angiomata (small, distended blood vessels, usually on the chest) may be observed