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The quality of log-linear regression and, consequently, the reliability of the extrapolated pharmacokinetic parameters (namely z , t , AUC 0 , AUC extra , V z , CL r and CL t ) was demonstrated by a determination coefficient, R 2 0.8

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[DOI] [PMC free article] [PubMed] [Google Scholar] 303.Farre R, van Malenstein H, De Vos R, Geboes K, Depoortere I, Vanden Berghe P, Fornari F, Blondeau K, Mertens V, Tack J, et al