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Given that HIF-2 is an important transcription factor in cancer progression and leads to poor prognosis 69,70 , these findings suggest that targeting HIF-2 might be an effective therapeutic strategy by inhibiting glutamine metabolism in these notorious cancers

The dysregulation at this level enhances the activation of glial cells

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Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits

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Study tools The detailed history All patients were subjected to the detailed history through direct interviews of the subject and/or caregiver as well as collecting the data from the filling system including demographic characteristics, history of VOCs including the number of VOCs in the last year, its frequency per month, type and route of analgesics received at home and during hospitalization, hospitalization history, the severity of VOC, duration of admission in days, as well as the history of other complications, comorbidities, and operations