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A growing body of preclinical research suggests that targeting the ferroptosis regulatory pathway centered on GPX4, including drug inhibitors, natural active compounds, gene or RNA intervention strategies, and novel local delivery systems, can alleviate cartilage degeneration and joint inflammation to varying degrees in experimental OA models

Skin moisturization and elasticity were measured by a cutometer, wrinkle depth was quantified using an Antera 3D image system of the face, and clinical evaluations were performed by a dermatologist for skin softness, smoothness, firmness, and wrinkles using a standardized scoring system

Metabolites produced by gut microbiota may influence brain neurons, and PD patients often experience gastrointestinal dysfunction

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

95 investigated the post-infection transcript dynamics of a field resistant line and of a susceptible line

Ferrous iron avidly interacts with compounds seeking electrons, such as oxygen or other oxidizing agent, and in the process is oxidized to the ferric (trivalent or Fe 3+ ) state