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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

Reduction of NO production in LPS-stimulated primary rat microglial cells by bromelain

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*Correspondence: Liang Yan, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Additionally, at an alkaline pH, TMAO remains uncharged (pKa of TMAO is 4.7) [27,28,29], protecting TMAO from cross-reaction with IACN, as previously reported [14]