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Under constant exposure, receptors are pulled off the cell surface and become less responsive over time (receptor desensitization). Higher doses maintain more signal against that fade

O., Ukoha, A

Aquat Toxicol 220:105406 Amer SA, El-Araby DA, Tartor H, Farahat M, Goda NI, Farag MF, Osman A (2022) Long-term feeding with curcumin affects the growth, antioxidant capacity, immune status, tissue histoarchitecture, immune expression of proinflammatory cytokines, and apoptosis indicators in Nile tilapia, Oreochromis niloticus

Duration of treatment was five times the half-life of each agent and the placebo was matched accordingly

Hypertension in particular has been the target of many therapeutic interventions and there are numerous studies that show beetroot, delivered acutely as a juice supplement [9,10,11] or in bread [12,13] significantly reduce systolic and diastolic blood pressure

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