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As a result of increasing ROS generation, one of the first events in atherogenesis, as well as in other CVDs correlated with endothelial dysfunction, is the oxidative modification of low-density lipoprotein (LDL) (Singh et al., 2002

conventional animal comparisons and microbiome sequencing studies investigate these questions

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Of note, AMPK has an Akt phosphorylation site on the C terminal domain of the alpha subunit, which, when bound by Akt, modulates the AMPK/LKB1 complex increasing chances of AMPK phosphorylation (Yan et al., 2018[164]), making it a potential therapeutic target