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Appropriate premedication with B12 and FA is considered helpful in preventing severe hematological AEs, consistent with the findings of previous reports [4, 29]

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SIRT1=silent mating type information regulation 2 homolog) 1, PINK1=PTEN-induced putative kinase, ATG5=autophagy-related protein 5, LC3B=Microtubule-associated protein 1 light chain 3 beta, PGC-1= Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, NMRI=nuclear magnetic resonance imaging Translation of experimental findings to clinical settings Rodent models of arsenic-induced renal injury exhibit pathological and biochemical features similar to those observed in human cohorts

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