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In a randomized, double-blind, placebo-controlled clinical study in 67 patients with severe traumatic brain injury, intravenous administration of dexanabinol (48 mg or 150 mg) within 6 hours of injury resulted in lower intracranial pressure and a reduced number of hypotensive episodes, indicating improvements in cerebral edema

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For example, mitochondria isolated from the rat whole brain, when exposed to Aos, produce more reactive oxygen species (ROS) [86]

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The significance of the differences ( P 0.05) was post hoc-tested using the least significant difference (LSD) method