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Dogs with IMHA are predisposed to thrombosis, particularly in pulmonary arteries (Carr et al 2002, DeLaforcade et al 2019), and hypoxic injury to tissues may contribute to hyperlactatemia and organ injury evident in many patients (MacNeill et al 2019)

It also may play a role in tissue damage repair by increasing blood flow to damaged tissues

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Additionally, a synergistic effect of low folate concentration and the MTHFR 6777T allele was linked to the atrophy of specific hippocampal subregions in AD patients [102]