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Animal studies reported bell-shaped curves for DSIP, and in the human work twice-daily dosing did not produce the night-sleep effect that once-daily morning injections did

Soy M, Keser G, Atagndz P, Tabak F, Atagndz I, Kayhan S

9 Broadly, current pharmacologic treatment strategies include serotonin-norepinephrine reuptake inhibitors such as venlafaxine and duloxetine, tricyclic antidepressants, and the anticonvulsants gabapentin and pregabalin as first-line therapies

Drugs Drug Candidates 3:184207

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