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Gpx activity in the liver of WT mice also was increased by Con A injection, and it was decreased in the liver of both saline- and Con A-injected Gpx1 KO mice (Figure 1b)

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Other studies have also evaluated pesticides using mitochondrial dysfunction as a method of toxicological analysis [49, 53, 54, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133]

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These two sources of variation are evidenced in Panel A and B, that illustrate trends in PCA scores as a function of the injection order corresponding to within-batch effects, and Panel B, where a tight clustering among batches indicative of a between-batch effect respectively