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Increased prevalence and incidence rates of HPV infection are closely associated with BV characterized by reduced Lactobacilli and increased anaerobic bacteria (Guo et al., 2012)

Mechanistically, S-thiolation of cysteine residues on IKK and related signaling proteins suppresses IB phosphorylation and limits NF-B (p65) nuclear translocation, resulting in consistent reductions in IL-1, IL-6, and TNF- across cellular and animal models