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Wang G, Yu S, Bao C: Effect of different levels of protein in-take on metabolism of protein, zinc and copper in rats

Nevertheless, the pooled analysis of 16 trials suggested improvements in the summary measure of patients' global functioning (assessed with the Clinical Global Impressions [CGI-I] scale) after 12 and 24 weeks of (but not after 52 weeks) of ALCAR treatment (1-3 g/day) and in cognitive performance (assessed with the Mini-Mental State Examination [MMSE] scale) after 24 weeks (but not at 12 or 52 weeks) (104)

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The molecular axis constituted by System Xc GSHGPX4 and its dysregulation in OA have been repeatedly verified and confirmed in multiple independent studies, establishing it as a closely watched potential therapeutic target for intervening in ferroptosis (Figure 1)

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