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After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity) and reaching pre-arrival body weights (38 g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation

This limitation was addressed by excluding individuals on improbable regimens from the relevant analyses

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Ongoing research is also focusing on identifying new targets, investigating the effectiveness of combination therapies, and exploring the use of targeted radiotherapy on tumor stem cells