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Exact statistical tests, sidedness, multiple-testing procedures, thresholds for significance and the definition of box plot elements (median, IQR, whiskers) are reported in the figure legends

doi: 10.1038/s41586-019-1707-0 45 LeeDHParkJSLeeYSHanJLeeD-KKwonSWet al

In brief, cells (210 5 ) were incubated with 10 M DCFDA (Sigma-Aldrich) at 37 C for 30 min, washed with PBS and then exposed to treatments, as indicated

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Some case reports have even raised concerns about long-term KD use and under the background of some diseases

The combination of a PRMT5 inhibitor and anti-PD1 therapy produced a significant reduction in tumour volume and an increase in CD4+ and CD8+ T cell infiltration compared to either therapy alone in vivo (45)