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However, the protein abundance of the CI subunit NDUFA9 was reduced in mitochondria from adipocyte Bmal1 KO mice, while NDUFA10 and NDUFS2 were trending lower but did not reach statistical significant ( P = 0.07 and P = 0.1, respectively) (Extended Data Fig

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Overall, the future of intranasal delivery for TBI looks promising, as it represents an efficient way for neuroprotective drugs to be delivered quickly, noninvasively, and directly to the brain cells or at the injured site

Bacteria or cells Amount of cells (104): Extract solution (mL): 500~1000:1 (Add 1mL of Extract solution to 5 million cells), ultrasonic with ice bath to break cells(300W,3s, interval 7s,total time 3 minutes)