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Description

Peptide amides were prepared on a NovaSyn TGR solid support (0.25 mmol g 1 , Supplementary Fig

In brief, exons 2-3 of the Mettl3 -201 transcript (ENSMUST00000022767.15) was selected as the knockout target

Acyltransferases mediating butyrylation exhibited distinct substrate specificities: in vitro studies demonstrated that CBP/p300 (CREB-binding protein/E1A binding protein p300) directly butyrylates both histone H4 and non-histone protein p53 [58], whereas Gcn5 mutation significantly reduced histone H3 butyrylation [60]