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Insulin-like growth factor binding protein-6 interacts with the thyroid hormone receptor 1 and modulates the thyroid hormone-response in osteoblastic differentiation

Cakosiski, I

This metabolic shift reduces central serotonin availability while increasing neuroactive kynurenine metabolites, such as quinolinic acid, which enhance glutamatergic neurotransmission and promote excitotoxicity