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An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1)

Benefits May support normal red blood cell formation May support normal nerve function May support normal neurological function May play a role in normal cardiovascular function May support normal energy metabolism These statements reflect the role of B12 as an essential nutrient as documented in the scientific literature

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Further, there were no significant changes in laboratory parameters, vital signs, or ECGs during the study in any treatment group, including placebo

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