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10.3390/nu13113744 79 JiangN.ZhaoH.HanY.LiL.XiongS.ZengL.et al (2020a)

48 children (ages ~312) were randomized to leucovorin (2 mg/kg per day, max 50 mg, split twice daily) or placebo

Enzymatic Antioxidants Several enzymes obstruct free radicals formation, some of them act directly in scavenging ROS (primary enzymes), whereas secondary enzymes play an indirect role by supporting other endogenous antioxidants (Figure 2)

Vitamin C neutralizes free radicals in the aqueous (water-based) parts of your cells

Pharmacol., 44: 1193-1193

For example, using drugs to change the tumor microenvironment leads to the loss of immunosuppression and immune monitoring, which leads to the disorder of ICD (129)