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Knapen MF, Mulder TP, Van Rooij IA, Peters WH, Steegers EA

Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha

In diffuse gliomas, TERTp mutations are associated with worse OS, with distinct prognostic implications depending on tumor grade and cooccurring mutations

The most common form of hereditary hemochromatosis is that due to p.Cys282Tyr homozygosity in HFE and manifests in adulthood

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2321-C HEPATOCYTE HEDGEHOG ACTIVITY CONTROLS NAFLD SEVERITY BY REGULATING SENESCENCE-ASSOCIATED SECRETOME Ji Hye Jun 1 , Kuo Du 2 , Seh-Hoon Oh 2 , Raquel Maeso Daz 2 , Rajesh Kumar Dutta 3 , Anna Mae Diehl 2 and Duke University, (1)Duke Universty, NC, (2)Duke University, (3)Duke University, Durham, NC Background: NAFLD and other inflammatory liver diseases induce hepatocyte DNA damage and senescence