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Artificial intelligence-driven approaches that integrate deep learning-based protein design with functional screening for isolation of long-acting GLP-1 RA are on the way to help in designing novel compound with improved stability and efficacy [92]

Funding This work is supported by research grants from the Canadian Institute of Health Research (MOP 201803PJ8) and the Alzheimers Association (PTC-18-543823) and made possible by Part the Cloud, as well as the Alzheimer Society Research Program (ASRP #21-11)

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

The Nitrate-Independent Blood Pressure-Lowering Effect of Beetroot Juice: A Systematic Review and Meta-Analysis

BPC-157 is studied for protective and signaling mechanisms: shielding cells from damage, reducing excessive inflammation, and promoting growth factor activity

Ginsburg, H., Krugliak, M., Eidelman, O