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10.1038/ki.2012.337 81 KaushalG

This data showed that overexpression of Pro1 could produce more -glutamyl phosphate involved in an alternative pathway for a small amount of GSH formation in S

These changes lead to reduced availability of NADPH for the normal functioning of neutrophils there by decreasing levels of the intracellular ROS scavengers, glutathione and modifies transcription factors activating pro-inflammatory genes (IL-6, TGF-, TGF-) [16]