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The slight acidity of the solution (pH approximately 3.04.0 at 0.1% concentration) protonates basic amino acid residues on poorly water-soluble peptides, increasing their net positive charge and improving electrostatic interaction with the surrounding aqueous solvent a mechanism that dramatically increases the solubility of many lyophilised peptide preparations that resist dissolution in neutral or alkaline aqueous conditions

Of the 9 patients who received topical antifungal therapy, 8 showed symptom improvement

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B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from multiple sclerosis, pernicious anaemia, Crohns or celiac disease