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parkeri fitness, pathogenesis and innate immune evasion are unclear

10.1007/s00432-018-2777-3 35

Additionally, hypermethylation of the Foxp3 gene promoter in T cells results in reduced Foxp3 expression, impairing Treg cell function and disrupting immune homeostasis, thereby exacerbating MS progression (83, 85)

In sporadic PD patients, the degree and prevalence of Complex I deficiency are heterogeneous

For the result of PCD prevalence estimation by the Bayesian framework in other gnomAD populations, the prevalence is 1:1,134,461 (95% confidence interval: 1:2,300,3251:650,711) in African American (AFR) population, 1:148,320 (95% confidence interval: 1:314,1551:82,852) in admixed American (AMR) population, 1:921,025 (95% confidence interval: 1:28,837,5931:211,888) in ASJ population, 1:1,964,440 (95% confidence interval: 1:13,880,6671:645,273) in Finnish in Finland (FIN) population, 1:282,613 (95% confidence interval: 1:413,7091:202,688) in NFE population, 1:84,707 (95% confidence interval: 1:404,3291:31,975) in South Asian (SAS) population, and 1:16,375 (95% confidence interval: 1:41,4101:8,272) in East Asian (EAS) population (Figure 3B)

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