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The microsomes were incubated with 500 M solutions of Dihexa, piroxicam, verapamil, and 7-ethoxycoumarin, as controls for low, moderate, and highly metabolized compounds, respectively, in 0.1 M Tris buffer with an NADPH-regenerating system at 37C

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Research Use Only: This product is supplied strictly for in-vitro laboratory and analytical research purposes only

The use of P5091 or P22077, two USP7 inhibitors, display a strong senolytic activity in several models of senescence 31

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