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Class I is further divided into two subclasses: class I A (PI3K, , and ) and class I B (PI3K)

BMC Biotechnol 4:32 Acknowledgments The authors would like to thank Huira Chong and Jennifer Aurandt for critical review of the manuscript

Human gut microbiota has gained much attention due to increasing evidence of compositional and structural changes of gut microbiota playing a vital role in various aspects of human health, including immune, metabolic, and neuro-behavioral traits (50)

Also, an extension from stomach epithelium protection to stomach endothelium protection (and thereby concept background stomach endothelium stomach epithelium protection) (21-24) permits cytoprotective agents as an endothelium protectants class (although this was not originally claimed) (21-24), and consequently, application in thrombosis and bleeding disorders (5, 8, 25-28)

Research indicates that NNMT expression correlates positively with insulin resistance, with plasma levels of the NNMT product 1-methylnicotinamide associated with increased body mass index and metabolic dysfunction

observed that patients with high cholesterol levels had significantly higher levels of Firmicutes than those in healthy patients