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Supporting this interpretation, a previous clinical study reported that individuals carrying SNPs associated with reduced GLUT2 expression exhibit greater responsiveness to metformin, further suggesting that decreased intestinal glucose absorption mediated by reduced expression of glucose transporters such as GLUT2 may play an important role in enhancing overall glucose homeostasis after metformin administration 52

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While most cases of delayed cutaneous hypersensitivity have been recorded in patients who received the Moderna vaccine, a few cases have been reported by recipients of the Pfizer vaccine, says Esther Freeman, M.D., Ph.D., director of Global Health Dermatology at Massachusetts General Hospital and principal investigator for the global COVID-19 Dermatology Registry

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