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Individuals with pre-existing arrhythmias, uncontrolled hypertension, or a history of substance use disorders are typically excluded from tesofensine research protocols

MOTS-c is a potent activator of AMPK (Adenosine Monophosphate-activated Protein Kinase)

Eussen SJ, De groot LC, Clarke R, et al

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The peptide demonstrates broad regenerative properties across multiple tissue types

So if your main barrier is appetite dysregulation, food noise, or post-meal cravings, AOD-9604 is not a like-for-like substitute for semaglutide or tirzepatide