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Of the three initially promising remyelinating agents (high-dose biotin, opicinumab and clemastine), only the antihistamine clemastine is still under investigation

Mechanistically, BPC-157 promotes fibroblast activity, modulates the nitric oxide system, enhances angiogenesis through vascular-endothelial growth factor, downregulates proinflammatory cytokines, and stimulates collagen remodeling (Figure 1)

In recent studies, several transcription factors, including FoxO3a, Atf3, REST, and KLF11, have been suggested to play a regulatory role in ferroptosis

Weight-Loss Surgery Gastrointestinal procedures such as bariatric surgery, or removal of part of the stomach, cause partial or complete loss of the cells that secrete hydrochloric acid and intrinsic factor, reducing B12 absorption

Al-Jishi E, et al

Interstitial cells of Cajal (ICC) dysfunction represents the cellular basis of gut dysmotility