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Galletti, R., Ferrari, S

S., Maeda, N

In contrast to essential amino acids that require multi-step biosynthesis, alanine can be made from pyruvate by a single transamination

The intracellular concentration of gamma-glutamylcysteine (GGC) is extremely low (~ 5 uM) when GS is present, thus GCL is considered the rate-limiting enzyme [6]