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First, semaglutide activates GLP-1 receptors in the brain, particularly in the hypothalamus, which reduces appetite and changes how you experience hunger

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai S, Yoshino J