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Upon glutamine deprivation, lung cancer cells increase the phosphorylated CCAAT/enhancer binding protein (p-C/EBP)-dependent metabolic protein called Sestrin2 to maintain ATP levels and prevent excessive production of ROS through differential regulation of mTORC1 and mTORC2 123

Scheid C, Hermann K, Kremer G, Holsing A, Heck G, Fuchs M, Waldschmidt D, Herrmann H-J, Shngen D, Diehl V, Schwenk A

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Additionally, the decreases in heart rate were not blocked by atropine, an anticholinergic agent, which indicates that the lowered heart rate was independent of parasympathetic activation [46]