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Prepare linkers using high-purity synthesis techniques and perform efficient conjugation with drugs and carriers, ensuring uniform drug loading, high conjugation efficiency, and molecular stability

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Thus, in addition to mechanisms leading to increased de novo lipogenesis triggered by ER stress, impaired mitochondrial FAO and decreased CPT-1 expression can further contribute to fatty acid accumulation and steatosis both in ALD and MASLD (Figure 1) [126, 127]