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Signal Transduct Target Ther 6(1):263 Zhao X et al (2022) New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction

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Currently, Novartis, Bristol-Myers Squibb (BMS), and other pharmaceutical companies are advancing related drug candidates, with some already in clinical development

One of the mechanisms for other viral co-infection to trigger KSHV reactivation is the secretion of inflammatory cytokines, such as oncostatin M (OSM), hepatocyte growth factor (HGF), interferon- (IFN-), and Toll-like receptors 7 and 8 (TLR7/8) (Mercader et al., 2000